Abstract
Coagulatory abnormalities are common in renal dysfunction in humans. The studies on coagulatory abnormalities in renal failure in dogs are limited. The present paper deals with coagulation profile in acute and chronic kidney disease in dogs. The haemostatic defects observed in acute renal dysfunction included thrombocytopaenia, prolonged capillary bleeding time (CBT), elevated D-Dimer and hypoantithrombinemia which indicated a hypercoagulable state. Prolongation of prothrombin time (PT), activated partial thromboplastin time (aPTT), elevated D-Dimer concentration and hypoantithrombinemia in chronic kidney disease indicated the presence of hypocoagulable state
Highlights
Prolongation of prothrombin time (PT), activated partial thromboplastin time, elevated D-Dimer concentration and hypoantithrombinemia in chronic kidney disease indicated the presence of hypocoagulable state
Detailed study were conducted in the cases to assess the coagulation status of animals based on platelet morphology and coagulation parameters such as capillary bleeding time (CBT), prothrombin time (PT), activated partial thromboplastin time, activated coagulation time (ACT), D-Dimer (DD), FDPs and antithrombin III (AT III) concentration (Table 1)
Compared to the acute renal injury, CBT, PT, activated partial thromboplastin time (aPTT), D-Dimer concentration were more elevated in the chronic kidney disease of this study.The prolonged CBT observed in both these cases might be due to thrombocytopaenia or platelet dysfunction (Mischke, 2014)
Summary
The present paper deals with coagulation profile in acute and chronic kidney disease in dogs. The haemostatic defects observed in acute renal dysfunction included thrombocytopaenia, prolonged capillary bleeding time (CBT), elevated D-Dimer and hypoantithrombinemia which indicated a hypercoagulable state. Prolongation of prothrombin time (PT), activated partial thromboplastin time (aPTT), elevated D-Dimer concentration and hypoantithrombinemia in chronic kidney disease indicated the presence of hypocoagulable state.
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