Coagulation Parameters Among Sudanese Individuals Vaccinated with Johnson and Johnson Vaccine at Khartoum State, 2022

Abstract

<i>Background: </i>A COVID 19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome corona virus 2. Ad26.COV2.S (Johnson & Johnson) vaccine is adenovirus vector-based vaccine that targets the spike protein of the SARS-CoV-2 virus, when it enters the body it stimulates the immune response. <i>Materials and methods: </i>This was a cross sectional study, health facility base, Conducted in Vaccine centre at Omer ben Alkhatab, Khartoum, Sudan during the period July to August, 2022 to estimate changes of coagulation parameters among Sudanese vaccinated with Johnson & Johnson vaccine. Sixty samples were collected from the Participants that took the first dose of Johnson & Johnson vaccine; thirty samples before the vaccination, and thirty after vaccination. The coagulation parameters were performing by different methods. <i>Results:</i> The means of parameters before the vaccination were; APTT was (36.2 ±3), PT was (15.8±2.4), INR (1.2 ±0.2), platelets (285.9 ±7.2), fibrinogen (243.4 ±4.6) and D-dimer (0.17±0.03). The means of parameters after the vaccination for the APTT, PT, INR, platelets count, fibrinogen and the D-dimer were; (35.2 ±2.9), (13.9±2.1), (1.21±0.3), (272.8±57.9), (284.2 ±53.3) and (0.37±0.8) respectively. When compared between the results of parameters per and post vaccination the results revealed that; there was significant decrease in the time for the APTT and PTT (p value ≤0.05), in significant differences with the INR and platelets count (p value ≥0.05), significant increase for the fibrinogen and D- dimer level (p value ≤0.05). While when compared the mean of the parameters with the age, genders, and symptoms there was insignificant differences (p value ≥0.05), except the D – dimer had a significant differences with the age and symptoms (p value ≤0.05).<i> Conclusion:</i> In the conclusion of this study there was significant decrease of the activated partial thromboplastin time (APTT), Prothrombin time (PT), and significant increase in fibrinogen and D-dimer level in the Sudanese individuals after the first dose of Johnson and Johnson Vaccine.