Coagulation factor VII gene polymorphisms and cardiovascular diseases in Iranian population

Abstract

AimThe association between coagulation factor VII (FVII) gene polymorphisms and FVII level and activity and also cardiovascular diseases (CVD) has been reported in several studies. The aim of this study was to determine whether two FVII gene polymorphisms including: −401G > T and HVR4 influence risk of CVD in Iranian population. MethodsA total of 110 patients with cardiovascular disease that confirmed by angiography (57 male and 53 female, mean age 55.4 ± 10.8 years old) and 110 age and sex match controls (54 male and 46 female, mean age 53.8 ± 9.7) without cardiovascular disease (confirmed by angiography) were genotyped for these two polymorphisms. ResultsAlthough TT genotype of −401G > T polymorphism was at a higher frequency among control group compared to patients (18.1% vs 16.3%), the difference was not statistically significant (P > 0.05). Also carriers of the H7-allele (H7H7) were at a higher frequency among control group in compare with patients group (23.6% vs 21.8%) but it was not statistically significant too (P > 0.05). ConclusionWe could not found any association between −401 G > T and HVR4 polymorphisms of coagulation FVII and CVD in Iranian population, but future studies with larger study groups are recommended for more evaluation of these associations.