Coagulation defect in horse plasma.

Abstract

Summary1. The delayed thrombin generation in samples of horse plasma was made normal by 1) addition of normal human plasma, or 2) addition of reabsorbed heated human serum, or 3) addition of washed human or horse platelets, or 4) freezing of the horse plasma with its normal content of platelets. 2. These results indicate that the clotting defect of the horse plasma investigated is caused by lack of a factor similar to the Hageman factor. 3. Blood platelets, after washing or freezing, apparently substitute for the effect of the lacking plasma factor. 4. The coagulation defects in horse plasma apparently reflect various types of hemophilioid deficiencies.