Abstract
Fibrinogen is a complex multifunctional glycoprotein that plays a key role during blood clotting. Thrombin-mediated conversion of fibrinogen into fibrin and the subsequent cross-linking by factor XIII results in the formation of the three-dimensional framework of the thrombus. In addition, fibrinogen promotes platelet adhesion and aggregation via interaction with a specific integrin receptor. Next to its essential function in normal hemostasis and wound repair fibrin(ogen) also exerts multiple regulatory effects and is involved in pathological processes such as thrombosis and atherosclerosis. Abnormal fibrin turnover has also been implicated in a number of respiratory diseases including acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and chronic interstitial lung diseases such as pulmonary fibrosis.
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