Abstract
Pregnancy is a physiological hypercoagulable state, preparing the mother for the hemostatic challenge of delivery. However, this is associated with an increased risk of venous thrombosis and placenta-mediated complications, which present major challenges for mother and fetus. Although these conditions are heterogeneous in their pathophysiology, hereditary and acquired thrombophilia has been associated with recurrent pregnancy loss and gestational vascular complications, such as early-onset pre-eclampsia and placental abruption. Prevention of such placenta-mediated complications, which collectively complicate up to 15% of pregnancies, is a major issue for women’s health. Prospective interventional studies stratified by current knowledge of pathophysiological mechanisms related to placental and systemic hemostatic alterations will impact on the management of pregnancies at risk of these complications.
Highlights
Pregnancy is a physiological hypercoagulable state, preparing the mother for the hemostatic challenge of delivery
Concentrations of tissue factor (TF) and free tissue factor pathway inhibitor (TFPI) are significantly increased in maternal plasma of pre-eclamptic women compared with normal pregnancy,[9] while the TFPI-to-TF ratio is significantly lower in patients with pre-eclampsia than in normal pregnancy
Higher maternal plasma concentrations of plasminogen activator inhibitor-1 (PAI-1) are observed in preeclampsia compared to normal pregnancy
Summary
Special Issue on Advances in Hematology Guest Editor: Benjamin Brenner, M.D. Ian A. M.D., F.R.C.P. (Glas), F.R.C.P.E., F.R.C.P., F.R.C.P.I., F.F.S.R.H., F.C.C.P., F.R.C.O.G., F.Med.Sci.,[1] Anat Aharon, Ph.D.,2,3 Benjamin Brenner, M.D.,2,3* and Jean-Christophe Gris, M.D., Ph.D.4
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