Abstract
The mechanism underlying pain symptoms in fibromyalgia (FM) is not fully understood. Oxidative stress has emerged as pathophysiological event occurring during the development of the disease. The present study aimed at investigating the efficacy of resveratrol associated with rice bran oil on fibromyalgia-like mice model. Subcutaneous injection of reserpine (0.25 mg/Kg) during 3 days produced fibromyalgia-like symptoms. Resveratrol and/or rice oil or pregabalin were administered through oral route in therapeutic (single dose) and preventive (four doses) schemes. In both schemes, treatment with resveratrol associated with rice bran oil and pregabalin significantly reduced mechanical allodynia and thermal hyperalgesia in animals. The preventive scheme displayed antidepressant effect which was demonstrated by the forced swimming test as well as reduced reactive species in the cerebrospinal fluid of reserpinized animals. Taken together, our data provide evidences that the intake of resveratrol associated with rice bran oil plays antinociceptive and antidepressant actions probably through reducing reactive species and suggests the involvement of oxidative stress in this model of FM as possible underlying mechanism of pathogenesis of the disease.
Highlights
Painful syndromes are highly prevalent among populations around the world
On the 4th day after the reserpine injections (0.25 mg/kg for three consecutive days), mice presented a reduction in the mechanical threshold tested by Von Frey filaments in comparison to the control group (p < 0.001, Figure 1), indicating mechanical allodynia
When we evaluated the changes caused by RSV (100 mg/kg once a day for four days), RSV + rice bran oil (RO) (10 mg/kg once a day for four days), RO (10 mL/kg once a day for four days), or PGB (30 mg/kg once a day for four days) treatments, we observed that Reactive Species (RS) levels in the cerebrospinal fluid (CSF) diminished in relation to the RES-SAL group (p < 0.05, Figure 8)
Summary
Painful syndromes are highly prevalent among populations around the world. Fibromyalgia (FM) is a common disorder characterized by chronic widespread pain along the body, especially prevalent in women [1, 2]. Beyond the pain as cardinal symptom in specific anatomical sites, FM patients complain of other debilitating conditions such as fatigue, anxiety, depression, and sleep disturbances [3, 4]. FM can be present with other comorbidities [5, 6], including irritable bowel syndrome [7], interstitial cystitis [8], chronic fatigue syndrome [9], and temporomandibular syndrome [10]. The heterogeneity of FM makes it difficult to understand its pathophysiology. The available therapeutic approaches for FM have limited effects once the side effects can be allied to the treatment [11] or even the treatment should be individualized [12]
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