Coadministration of PDE-5 inhibitors with gatifloxacin has minimal effect on the QTc interval in healthy male subjects

Abstract

patients were randomized into 2 groups: trimetazidine group (n = 60) and control group (n = 70). All patients were treated conventionally, and in addition, trimetazidine group patients received trimetazidine 20 mg orally every 8 hours starting after randomization and continued throughout hospitalization. A 12-lead resting electrocardiogram was recorded within 24 hours and 5 days after acute anterior myocardial infarction. P-wave dispersion was calculated by subtracting the minimum P-wave duration from the maximum P-wave duration of the 12 leads if the P-wave duration was measurable in more than 7 leads. Results: There was no significant difference in the baseline characteristics of patients (Table 1, P N.05). P-wave dispersion at the fifth day was significantly lower than electrocardiographic measurements at the first day in patients in the trimetazidine group. However, P-wave dispersion showed no significant difference between fifthand first-day electrocardiography in patients with control group (Table 2, P N .05). Conclusions: It is concluded that trimetazidine decreases P-wave dispersion after a first anterior AMI. Although, further studies are required.