Abstract
The aim of this study was to evaluate the effects of aluminum sulfate (alum) with propolis (PR) on uterine leiomyoma (UL) in rat model. One hundred and four female Wistar rats (180-200g) were allocated into two main groups of control (Co, n = 8) and experiment (UL model [estradiol benzoate 200μg/kg/IM twice/week/8weeks] with/without treatment) defined in 13 subgroups with/without treatment with coil oil (UL + COi), PR (100 or 200mg/kg) as UL + PR100 or 200, alum (35, 75 or 150mg/Kg) as UL + AL 35, 75, or 150, and PR (100mg/kg or 200) with alum (35, 75, or 150mg/Kg) as UL + PR100 or 200 + AL35, 75, or 150. Subgroups received doses of therapeutics for 14days (IP). In the end, rats were sacrificed, and the uteri were isolated for molecular and histopathological investigations. The myometrium thickness, collagen contents, and gene expression of MMP-2 and 9 increased significantly in experimental groups with/without treatment (P˂0.05). PR administration (100 and 200mg/kg) alone or with alum (35 and 75mg/kg) significantly decreased myometrium collagen contents and the gene expression and protein concentration of MMP-2 and 9 compared with UL and UL + Coi subgroups (P˂0.05). Alum (75mg/kg) with PR (200mg/kg) could improve UL features and reduce MMP-2 and 9 gene expression.
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