CO2-expanded liquids as solvents to enhance activity of Pseudozyma antarctica lipase B towards ortho-substituted 1-phenylethanols

Moeko Otsu,Yuichi Suzuki,Afifa Ayu Koesoema,Hai Nam Hoang,Mayumi Tamura,Tomoko Matsuda

doi:10.1016/j.tetlet.2020.152424

CO2-expanded liquids as solvents to enhance activity of Pseudozyma antarctica lipase B towards ortho-substituted 1-phenylethanols

Moeko Otsu, Yuichi Suzuki + Show 4 more

https://doi.org/10.1016/j.tetlet.2020.152424

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Journal: Tetrahedron Letters	Publication Date: Sep 5, 2020
Citations: 8

Affiliation: Tokyo Institute of Technology, Ho Chi Minh City University of Technology

#CO2-expanded Liquids #Pseudozyma Antarctica Lipase + Show 6 more

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Abstract

Pseudozyma (Candida) antarctica lipase B (CAL-B, Novozym 435®) is one of the most widely used and outstanding biocatalysts. However, CAL-B-catalyzed transesterification of ortho-substituted 1-phenylethanol analogs suffers low conversion. In this research, the reactions were accelerated by using CO2-expanded liquids, liquids expanded by dissolving pressurized CO2, such as CO2-expanded hexane or CO2-expanded MeTHF.

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