Abstract
The use of indirect comparisons to estimate efficacy estimates is established in the NICE HTA process. Network meta-analysis (NMA) allows a comparison to be made between interventions that have been assessed in different clinical trials where common comparators link studies. However, in cases where only single arm trials, trials with very different populations or non-linking trials are available, alternative statistical approaches such as matching-adjusted indirect comparison (MAIC) and simulated treatment comparison (STC) can be used.
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