Abstract

Venetoclax+rituximab (VEN+RTX) is a potent anti-leukemic therapy for relapsed/refractory chronic lymphocytic leukemia (R/R CLL), superior to bendamustine+rituximab (BEND+RTX) based on the results of the MURANO trial. However, the relative efficacy and safety of VEN+RTX compared to other treatment options remain unknown. This study aimed to compare VEN+RTX with other possible therapies for R/R CLL, including BTK and PI3K inhibitors, chemotherapy, and/or immunotherapy.

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