Abstract
Neurocognitive impairment affects about 50-90% of brain metastases patients who receive radiation therapy. However, literature search revealed that memantine had potential to prevent neurocognitive impairments induced by radiation therapy. However, due to lack of comprehensive data on memantine in prevention of neurocognitive impairments following radiation therapy, we conduct this systematic review to gather the safety and efficacy data of memantine therapy in prevention of neurocognitive dysfunction induced by radiation therapy in brain metastases patients.
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