Abstract
Improved treatments have raised cancer survival rates and increased the number of patients needing fertility preservation. A major obstacle to efficient ovarian tissue autotransplantation is graft ischemia. Endothelial cells (ECs) exhibit the unique capacity to auto-assemble neovascular networks following in vivo transplantation of single cell suspensions. Here, we show that co-transplantation of exogenous ECs improve survival and follicular reserve of xenografted ovarian tissue by accelerating anastomosis of blood vessels at the interface of host and graft.
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