Co-Supplementation of Vitamin E & Nigella sativa Improved the Endometrial Thickness in Mice

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Background: The thin endometrial lining has been reported to be associated with significant complications in maintaining a healthy pregnancy. Studies have been conducted to find ways to improve this condition, and one of the possibilities is through micronutrient intake. Vitamin E and Nigella sativa (NS) are the two potential sources of micronutrients that could play essential roles in improving endometrial thickness. Purpose: The present study was conducted to determine the effect of vitamin E and NS supplementation on endometrial thickness in normal (not induced to any disease) mice. Methods: Twenty-four balb/c mice were divided into four groups with six mice each; Group A as negative control (no treatment), Group B given with vitamin E (400 mg/kg), Group C given with NS (200 mg/kg) and Group D given with both vitamin E (400 mg/kg) and NS (200 mg/kg). The uterus histological sections from each group were evaluated for endometrial thickness and other structures of the uterus components were also observed. Results: Co-supplementation of vitamin E and NS have a significantly higher endometrial thickness (131.84 + 14.48μm) compared to the control group (88.08 + 11.49μm) and other uterus structures were not disrupted. Conclusion: The co-supplementation of vitamin E and NS could enhance the endometrial thickness without inducing any disruption to the other structures of the uterus. KEYWORDS: Endometrial thickness; vitamin E; Nigella sativa; uterus histology.