Abstract
The amino acid content of Torpedo synaptosomes was investigated. It was found that glutamate and taurine were particularly enriched, their concentration exceeding that of acetylcholine by 50-60%. Other amino acids such as alanine, gamma-aminobutyric acid (GABA), glycine, leucine and phenylalanine were also present, but in smaller quantities. The neurotransmitter-releasing agents gramicidin, calcium ionophore A23187, High K+ and Glycera venom all released acetylcholine, as shown previously. However, both glutamate and taurine were found to be released by these agents together with acetylcholine. The efflux of all 3 compounds was found to be largely calcium dependent.
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