Abstract

An unusual rise in blood glucose linked with the use of glucocorticoids in a patient with or without a prior history of diabetes mellitus is referred to as steroid-induced diabetes mellitus. The term steroid refers to a group of chemicals that have varied physiological effects. Hydrocortisone are a class of hormones that comprises both lab-made and naturally occurring hormones. Steroids are naturally occurring hormones in the human body. Corticosteroids have a wide spectrum of effects, from solely glucocorticoid to solely mineralocorticoid, and steroid compounds are chosen based on their suitability for a particular therapy. A drug may have anti-inflammatory resources, it could also have mineralocorticoid action, which lowers blood pressure. Steroids are drugs that have been used extensively in a variety of conditions. Glucocorticoids, despite being frequently recommended for their anti-inflammatory and immunosuppressive characteristics, have a number of side effects, with hyperglycemia being one of the most common and representative. In diabetic individuals, corticosteroids are generally contraindicated due to the danger of altering glucose control and resulting in severe decompensation. However, if given early and in a well-controlled regimen, corticosteroid medication can be useful in some patients. With good knowledge of the pharmacokinetics of the glucocorticoid utilized, glucose disequilibrium after withdrawal can be predicted.

Highlights

  • Steroids have been used for a variety of purposes since their discovery in 1935

  • An unusual rise in blood glucose linked with the use of glucocorticoids in a patient with or without a prior history of diabetes mellitus is referred to as steroid-induced diabetes mellitus

  • The term steroid refers to a group of chemicals that have varied physiological effects

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Summary

INTRODUCTION

Steroids have been used for a variety of purposes since their discovery in 1935 These adrenal gland isolates were considered to be solely effective in patients with Addison disease [1]. Corticosteroids are a type of steroid that is used to treat disease. Corticosteroids are utilized to treat dangerous swelling, but they can cause DM, which is known as steroid diabetes. It can cause non-diabetic people to have higher blood sugar levels This can happen because steroid treatment causes the liver to produce more sugar, steroids make it difficult for sugar to leave the bloodstream, and the body may develop insulin resistant while on steroids [5]

MECHANISTIC PHARMACOLOGY AND PHYSIOLOGY OF STEROIDS
How Do Steroids Work?
Mechanisms of Action of Corticosteroids
Types of Steroids
Topical steroids
Steroid inhalers
Steroid injections
How Do Steroid Medications Affect Blood Glucose Levels?
CORTICOSTEROIDS IN DIABETES PATIENTS INFECTED WITH COVID-19
What Role may a Diabetologist Play in the Post-COVID-19 Care Strategy?
Clinical
CONCLUSION
Findings
Steroid medications and diabetes fact
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