Co-relation between inflammatory biomarkers and COVID-19 progression

Abstract

Background & Objective: - Coronavirus Disease-19 (COVID-19) disease has caused considerable morbidity and mortality worldwide. The present study aims to investigate the prognostic significance of the inflammatory markers and to augment our present knowledge of these biomarkers to help in risk stratification. Methodology - The proposed study is a retrospective observational study on COVID-19 positive patients admitted in the ICU of Hospital of Government Doon Medical College, Dehradun, India from November 2020 to January 2021. Patients were categorized in to three groups moderate, severe and critical as per the criteria mentioned in methodology section in detail. Statistical Analysis- To explore the risk factors associated with illness severity of COVID-19, we categorized the patients into two groups, and one is moderate and severe and second is critical. Potential predictive variables included the following case characteristics on admission: demographic features and, comorbidity, clinical signs and symptoms and laboratory findings. Results- Sixty-two patients were enrolled in this study with mean age of 63.24±20.12 of which 44(70.96%) were males and 18(29.03%) were females. Multiple number of patients had comorbidities with diabetes 36(58.06%) patients, followed by hypertension in 24(38.70%).