Co-Processing of Excipients: A Review on Excipient Development for Improved tabletting Performance

Abstract

Tablet manufacturing has been changed by the introduction of the direct-compression process and high-speed machines. These two developments have increased the demands on the functionality of excipients in terms of flow and compression properties. Direct compression is the preferred method for the preparation of tablets. The co-processing is the most widely explored method for the preparation of directly compressible adjuvants because it is cost effective and can be prepared in-house based on the functionality required. This review article is in pursuit of giving detailed information on the sources of new excipients, potential advantages of co-processed excipients, material characteristics required for co-processing, methods of preparing directly compressible adjuvants and various co-processed excipients for direct compression available in the market.