Abstract
Chimeric antigen receptor (CAR) Tcell therapies are limited by antigen escape and on-target/off-tumor toxicity. In addressing these challenges, Haubner etal. develop an "IF-BETTER" strategy. Their combinatorial chimeric co-stimulatory receptor with an attenuated CAR enhances acute myeloid leukemia (AML) killing while protecting healthy progenitors, highlighting the potential to leverage cooperative CAR designs.
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