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Abstract
Colistin resistance genes mcr-3 and mcr-1 have been detected in an Escherichia coli isolate from cattle faeces in a Spanish slaughterhouse in 2015. The sequences of both genes hybridised to same plasmid band of ca 250 kb, although colistin resistance was non-mobilisable. The isolate was producing extended-spectrum beta-lactamases and belonged to serotype O9:H10 and sequence type ST533. Here we report an mcr-3 gene detected in Europe following earlier reports from Asia and the United States.
Highlights
Colistin resistance genes mcr-3 and mcr-1 have been detected in an Escherichia coli isolate from cattle faeces in a Spanish slaughterhouse in 2015
In June 2017, Yin et al detected a third mobile colistin resistance gene mcr-3 on an IncHI2-type plasmid, pWJ1, in a porcine E. coli isolate from Malaysia [1]
The first plasmid-mediated polymyxin resistance mechanism, mcr-1, was reported in 2016 by Liu et al in human E. coli and K. pneumoniae collected from five provinces in China between April 2011, and November 2014 [4]
Summary
Co-occurrence of colistin-resistance genes mcr-1 and mcr-3 among multidrug-resistant Escherichia coli isolated from cattle, Spain, September 2015. Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de Extremadura, Cáceres, Spain 9. Citation style for this article: Hernández M, Iglesias MR, Rodríguez-Lázaro D, Gallardo A, Quijada NM, Miguela-Villoldo P, Campos MJ, Píriz S, López-Orozco G, de Frutos C, Sáez JL, Ugarte-Ruiz M, Domínguez L, Quesada A. Colistin resistance genes mcr-3 and mcr-1 have been detected in an Escherichia coli isolate from cattle faeces in a Spanish slaughterhouse in 2015. We found an Escherichia coli isolate carrying the mcr-3 gene among other isolates expressing colistin resistance It was sampled in cattle faeces at the time of slaughter in Spain in September 2015. The aim of this paper is to describe the presence of mcr-3 in Europe in a strain carrying the mcr-1 gene
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