Co-immobilization of chitosan and dermatan sulfate from Raja montagui skin on polyethylene terephthalate surfaces: Characterization and antibiofilm activity

Abstract

ABSTRACTIn this work, polyethylene terephthalate (PET) was chemically modified by covalent co-immobilization of two separate layers of bioactive polymers composed of chitosan and a new dermatan sulfate isolated from Raja montagui skin. The new materials obtained were characterized by determination of carboxyl groups, ATR-FTIR spectroscopy, drop water contact angle, SEM, and TGA measurements. The different immobilizations modified the surface characteristics; especially when the first layer was dermatan sulfate (PET–DS–Chito) which presented the best surface wettability (71 ± 3°). It also reduced the ability of Staphylococcus epidermidis to form biofilm on PET surfaces which could decrease the virulence of vascular prosthesis infections.