Abstract
In this study a cobalt(II) complex of quercetin was synthetized in the solid state with the general formula Co(C15H9O7)2∙2H2O. The FT-IR, elemental analysis, and UV/Vis methods were used to study the composition of the complex in a solid state and in a water solution. The anti-/pro-oxidant activity of quercetin and the Co(II) complex was studied by means of spectrophotometric DPPH (2,2-diphenyl-1-picrylhydrazyl), FRAP (ferric reducing antioxidant activity) and Trolox oxidation assays. The cytotoxicity of quercetin and Co(II)-quercetin complex in HaCat cell lines was then established.
Highlights
Flavonoids are a category of plant hydroxylated phenolic compounds with an aromatic ring structure and include quercetin [1,2,3]
The cobalt(II) complex of quercetin with the formula Co(C15 H9 O7 )2 ·2H2 O was synthetized in its solid state in pH = 7.4
In line with the above-cited reports showing a protective role for quercetin in the amelioration of the oxidative stress-related toxicity of cobalt [34], the presented results indicate that the obtained Co(II)-quercetin complex showed higher antioxidant activity than quercetin alone in the DPPH and FRAP assays
Summary
Flavonoids are a category of plant hydroxylated phenolic compounds with an aromatic ring structure and include quercetin [1,2,3].
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