Abstract
Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and accounts for 2 to 3% of adult malignant tumors. This study proposed novel co-expression genes in RCC and investigated the curcumin effect on the expression of this gene in human cancer cells (ACHN). In this experimental study, the co-expression networks were predicted from different criteria for RCC by bioinformatics methods and employing RT-qPCR analysis; the mRNA levels of the selected genes were compared between curcumin-treated (24, 48, and 72 h) and untreated groups. The lncRNA-miRNA-mRNA interaction was created. RT-qPCR showed that the expression of c-Maf and LINC01077 in curcumin-treated ACHN was different from that of the un-treated ACHN. Our results suggest that the newly identified molecular pathway was affected by curcumin, proving that this drug has an anti-cancer effect.
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