Abstract
OBJECTIVE: Increased maternal age is accompanied by changes in metabolic activity of oocytes. As mitochondria are exclusively maternally inherited, alterations in their activity may severely compromise future embryo development. The objective was to compare the effects of maternal treatment with CoQ10, resveratrol or R-alpha lipoic acid (ALA), known mitochondrial nutrients, on MMP, reactive oxygen species (ROS) and mitochondrial DNA copy number in oocytes from aged ICR mice with placebo treated (aged control) or 10 week old (young control) mice.
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