Co/Cu Co‐Catalyzed Carbonylation of Alkyl Iodides and Thioesters

Abstract

AbstractInspired by the unique and ubiquitous nature of thioesters, great attention has been focused on the synthesis of thioesters. However, the harsh reaction conditions and equivalent oxidant required can still limit their applications. Here, a salcomine/IPrCuCl co‐catalyzed carbonylative thioalkylation of alkyl iodides using simple thioesters as a thiol surrogate is developed. This catalytic protocol displayed a good functional groups tolerance. The current work provides an inspiring example of the non‐nobel metal‐catalysed carbonylation for the synthesis of chalcogen‐containing compounds.