Abstract
CNS Control of Cardiac Rhythm. The purpose of our studies was to determine brain areas that influence cardiac rhythm. Studies were performed in anesthetized cats and indicate that a yet undetermined site in the hindbrain involving GABAergic mechanisms has a major influence over cardiac rhythm. In addition, a serotonergic mechanism involving 5‐HT2 receptors in the subretrofacial nucleus is responsible for selective activation of sympathetic neurons to the ventricle of the heart. Our data also indicate that neurons in the area postrema exert a major effect on cardiac rhythm. Finally, the question of whether pain‐induced changes in cardiovascular function involves neurons in the subretrofacial nucleus is also addressed.
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