Abstract
The purpose of research — improvement of CNS pathology diagnostic in children with enterovirus-71 infection during epidemic and interepidemic periods. The study involved 64 patients with enterovirus-71 infection at the age from 6 months to 14 years with CNS pathology, including 52 patients during epidemic period and 12 children during interepidemic period. The disease is characterized by the appearance at the first two days of fever, murrian-like, catarrhal, lymphoproliferative syndromes. On the third day of illness joined symptoms of meningitis, meningoencephalitis, encephalomyelopoliradiculoneuropathy and neuropathy. CNS pathology during interepidemic period often occurs in children with burdened history, not attending organized groups, is characterized by high frequency ncephalomyelopoliradiculoneuropathy and neuropathy, often associated with febrile fever and splenomegaly, a rare manifestation murrian-like syndrome. These features should be considered in the disease diagnosis during epidemic and interepidemic periods
Highlights
Обследовано 64 больных энтеровирусной-71 инфекцией в возрасте от 6 месяцев до 14 лет с поражением ЦНС, в том числе в период эпидемической вспышки — 52 пациента, в межэпидемический период — у 12 детей
The disease is characterized by the appearance at the first two days of fever, murrian-like, catarrhal, lymphoproliferative syndromes
Pathology during interepidemic period often occurs in children with burdened history, not attending organized groups, is characterized by high frequency encephalomyelopoliradiculoneuropathy and neuropathy, often associated with febrile fever and splenomegaly, a rare manifestation murrian-like syndrome. These features should be considered in the disease diagnosis during epidemic and interepidemic periods
Summary
Обследованы 64 ребенка в возрасте от 6 месяцев до 14 лет с комбинированной формой ЭВИ-71 с поражением ЦНС. Диагноз оставлен на основании данных эпидемического анамнеза, клинической симптоматики и подтвержден методом иммуноферментного анализа (тест-системы «Вектор-Бест, Россия), полимеразной цепной реакции (ПЦР) c использованием тест-систем «АмплиСенс Enterovirus-FL» и «АмплиСенс Enterovirus 71-FL». У 52 пациентов первой группы (81,3%) патология ЦНС развилась в эпидемический период заболева-. Патология ЦНС у детей с энтеровирусной-71 инфекцией в эпидемический и межэпидемический периоды. Анамнез жизни больных ЭВИ-71 с поражением ЦНС с учетом формы заболеваемости
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