Abstract
Withania coagulans (Stocks) Dunal (Solanaceae) have been reported with various uses such as emetic, sedative, diuretic, alterative in chronic liver disorders, dyspepsia, intestinal infections and colic pain. This study aims to investigate the central nervous system (CNS) depressant, anxiolytic and analgesic effects of methanolic extract of W. coagulans. CNS depressant activity of crude methanolic extract of W. coagulans fruits was evaluated using standard animal behavioural models such as open field, cage crossing, rearing and traction test. Anxiolytic activity was evaluated through forced swimming test whereas analgesic activity was carried out via acetic acid induced writhing and formalin test in mice. The extract (100 and 250mg/kg) showed a dose-dependent suppression of motor and exploratory (Neuropharmacological) activity for mice in open field, cage crossing, rearing and traction test. Significant writhing effect i.e. decrease in number of writhes as well as analgesic effects were observed (P<0.05).The findings of current research work supports the CNS sedative and analgesic potential of W. coagulans. Keywords: Analgesic; Writhing test; Balochistan; Khuzdar; Withania coagulans http://dx.doi.org/10.19045/bspab.2017.60066
Highlights
Paneer bandh, is distributed mostly in theThe family Solanaceae is famous for plantsMediterranean region, ranging to with potent medicinal properties [1].South Asia [2,3,4]
Material and methods Plant material The Fruits of W. coagulans were collected from Khuzdar district of Balochistan in the month of June
The results showed that 250 mg/kg dose of W. coagulans produced anxiolytic effect (Table 1)
Summary
Paneer bandh, is distributed mostly in theThe family Solanaceae is famous for plantsMediterranean region (east), ranging to with potent medicinal properties [1].South Asia [2,3,4]. Paneer bandh, is distributed mostly in the. The family Solanaceae is famous for plants. Mediterranean region (east), ranging to with potent medicinal properties [1]. South Asia [2,3,4]. In Pakistan, it is found in Withania coagulans (Stocks) Dunal, a shrub Number of writhes experiential in every mice was calculated for thirty (30) minutes whereas the %age protection compared to abdominal writhing was utilized as a tool to measure the degree of analgesia using the formula [28]
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