Abstract
Central nervous system manifestations of primary human herpesvirus-6 (HHV-6) are described in 9 children, ages 3 to 24 months, with HHV-6 DNA in the cerebrospinal fluid, in a prospective study at the University of Helsinki, and other centers in Finland.
Highlights
Central nervous system manifestations of primary human herpesvirus-6 (HHV-6) are described in 9 children, ages 3 to 24 months, with HHV-6 DNA in the cerebrospinal fluid, in a prospective study at the University of Helsinki, and other centers in Finland
In 6 children, HHV-6 DNA was present in CSF on days 1 to 4 after onset
No HHV-6 specific antibodies were detected in the CSF
Summary
Central nervous system manifestations of primary human herpesvirus-6 (HHV-6) are described in 9 children, ages 3 to 24 months, with HHV-6 DNA in the cerebrospinal fluid, in a prospective study at the University of Helsinki, and other centers in Finland. Of 393 young children with neurologic infections evaluated in 1995 and 1996, 32 had serological HHV-6 diagnoses, and of 21 less than 2 years of age, 9 tested positive for HHV-6 on the CSF by polymerase chain reaction. In 6 children, HHV-6 DNA was present in CSF on days 1 to 4 after onset. In 2 cases, PCR was negative on days 1 and 2, but was positive on days 9 and 17.
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