Abstract
The amin- and phenyl substituted 6,8-dioxabicyclooctanes 10 and 11 show distinct CNS-activities. Intensity and profile depend on the type of amine and the stereochemistry of the products. Therefore, we have synthesized 6,8-dioxabicyclooctanes with different amine-phenyl distances and examined their CNS-activities on mice as well as by receptor binding studies with the PCP-binding site which is part of the NMDA-receptor-complex.
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