CNN-OSBO Encoder-Decoder Architecture for Drug-Target Interaction (DTI) Prediction of Covid-19 Targets

Abstract

Drug Target Interaction (DTI) prediction is an important factor is drug discovery and repositioning (DDR) since it detects the response of a drug over a target protein. The Coronavirus disease 2019 (COVID-19) disease created groups of deadly pneumonia with clinical appearance mostly similar to SARS-CoV. The precise diagnosis of COVID-19 clinical outcome is more challenging, since the diseases has various forms with varying structures. So predicting the interactions between various drugs with the SARS-CoV target protein is very crucial need in these days, which may leads to discovery of new drugs for the deadly disease. Recently, Deep learning (DL) techniques have been applied by the researches for DTI prediction. Since CNN is one of the major DL models which has the ability to create predictive feature vectors or embeddings, CNN-OSBO encoder-decoder architecture for DTI prediction of Covid-19 targets has been designed Given the input drug and Covid-19 target pair of data, they are fed into the Convolution Neural Networks (CNN) with Opposition based Satin Bowerbird Optimizer (OSBO) encoder modules, separately. Here OSBO is utilized for regulating the hyper parameters (HPs) of CNN layers. Both the encoded data are then embedded to create a binding module. Finally the CNN Decoder module predicts the interaction of drugs over the Covid-19 targets by returning an affinity or interaction score. Experimental results state that DTI prediction using CNN+OSBO achieves better accuracy results when compared with the existing techniques.