Abstract
Methods: 200 cancer patients completed the Utility-Based Questionnaire-Cancer (UBQ-C), a validated 34-item cancerspecific instrument which includes scales of health status, overall QoL, disabilities and distresses. Patients were interviewed to elicit time trade-off (TTO) utilities for their own health states. A global QoL measure was derived from a weighted combination of the UBQ-C scales based on linear regression of health status on the individual scales. An equation to convert global QoL into utility was derived. Validity was examined using baseline data from a RCT of advanced breast cancer chemotherapy (n=290).
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