Abstract
CMR-based 3D statistical shape modelling reveals left ventricular morphological differences between healthy controls and arterial switch operation survivors
Highlights
Left ventricular ejection fraction (LVEF) late after arterial switch operation (ASO) is often normal
ASO-type shape features were not associated with BSA (r = 0.000; p = 1) or LVEF (r = -0.296; p = .080), but correlated with higher indexed end diastolic volume (iEDV) (r = 0.548; p = .001) and zEDV (r = 0.539; p = .001)
Using a statistical shape modelling framework (SSM) framework based on Cardiovascular magnetic resonance (CMR), distinct 3D shape features could be associated with LV morphology post ASO
Summary
Left ventricular ejection fraction (LVEF) late after arterial switch operation (ASO) is often normal. Some studies have shown increased indexed end diastolic volume (iEDV) and ventricular mass when compared to healthy controls. We sought to identify LV morphological differences between patients with transposition of the great arteries (TGA post ASO) and matched healthy control subjects. We hypothesised that besides a mere increase in ventricular volume, characteristic shape features can be associated with LV morphology post ASO. Ventricular shape being difficult to quantify using traditional morphometrics, a novel, validated non-parametric statistical shape modelling framework (SSM) was used to analyse 3D anatomical models without the need for landmarking
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