Abstract
Radiotherapy Sensitization Enhancing the cellular radiosensitivity is instrumental for improving the efficacy of tumor radiotherapy. In article number 2206415, Junping Wang, Cheng Wang, and co-workers report a tumor-penetrating nanomaterial iCoDMSN constituted with dendritic mesoporous silica nanoparticles and iRGD peptide-conjugated [email protected] nanodots. By decreasing KEAP1 expression and upregulating nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase 1 (HMOX1), iCoDMSN expands the labile iron pool in cancer cells and initiates ferroptosis, whereby the nanomaterial sensitizes cancer cells to ionized radiation and eliminates the tumors combined with radiotherapy.
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