Abstract
Cluster headache is a severe headache disorder with considerable impact on quality of life. The pathophysiology of the disease remains poorly understood. With few specific targets for treatment, current guidelines mainly include off-label treatment with medication. However, new targets for possible treatment options are emerging. Calcitonin gene-related peptide (CGRP)-targeted medication could become the first (cluster) headache-specific treatment option. Other exciting new treatment options include invasive and non-invasive neuromodulation techniques. Here, we provide a short overview of new targets and treatment options that are being investigated for cluster headache.
Highlights
Cluster headache is one of the primary headache disorders
Patients suffer from attacks of severe unilateral pain that is located in the orbital, retro-orbital, or temporal regions and lasts for 15 to 180 minutes
Other studies have shown lower scores on the 36-Item Short Form Health Survey (SF-36) in patients with episodic cluster headache during an active bout and in chronic cluster headache compared with healthy controls[4,5]
Summary
F1000 Faculty Reviews are written by members of the prestigious F1000 Faculty. They are commissioned and are peer reviewed before publication to ensure that the final, published version is comprehensive and accessible. The reviewers who approved the final version are listed with their names and affiliations. Any comments on the article can be found at the end of the article
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