CLRM-08 TAILORING CLINICAL TRIALS TO INCREASE PATIENT ENGAGEMENT: IMPACT ON PATIENT-REPORTED OUTCOMES IN ONCOLOGY

Abstract

Abstract BACKGROUND As regulators put more attention on patient-reported outcomes (PROs) in oncology clinical trials, it is vital to understand patient preferences and motivation for completing PROs. We investigated preferences and motivations for symptom reporting and how this may differ between participants with cancer and with other chronic non-oncology diseases. METHODS Participants completed an online survey focusing on preferences for using devices to report symptoms and what motivates them to complete PROs. Statistical analyses included a descriptive analysis of responses and Chi-Squared tests to examine differences between subgroups (oncology vs. participants with arthritis, diabetes, and chronic obstructive pulmonary disease). RESULTS Participants with cancer (N = 16) preferred using their own smartphone (31%) over going to a website (19%) or using a study-dedicated device (6%) to report symptoms, with 44% being happy with any option (44%). 88% of participants reported that receiving regular information to help manage their symptoms would motivate them the most to complete their PROs on a regular basis. Receiving a small financial compensation (81%) and knowing that their data was being reviewed by a healthcare professional (75%) were also strong motivators to complete PROs. The least preferred motivator was compensation in the form of charity donations (25%). Preference for reporting symptoms differed between subgroups (p=0.04), such that participants with cancer showed a higher preference for using their own smartphone compared to the non-oncology subgroup (N=30). The non-oncology subgroup was more likely to report notifications and alarms (p=0.04) as strategies that would encourage them to complete PROs. CONCLUSION This exploratory analysis suggests the importance of considering a range of symptom reporting strategies and the potential for tailoring strategies to fit patient preferences. The preference to use personal smartphones to report symptoms in participants with cancer suggests that a Bring-Your-Own-Device (BYOD) strategy may be particularly suited for oncology clinical trials.