Abstract
A distinctly new pathologic entity that causes steroid resistant nephrotic syndrome has been described by Jennette and Hipp. Clq nephropathy gets its name from the strong positivity of Clq localized by immunofluorescence. Reactions for C3, IgG and IgM are present, with a mild reaction for IgA occuring in some cases.The ultrastructural features of Clq glomerular nephropathy (Clq GN) and systemic lupus erythmatosis glomerular nephropathy (SLE GN) are strikingly similar in that they both demonstrate mesangial cell proliferative activity, mesangial dense deposits, and subendothelial or subepithelial dense deposits. One ultrastructural difference between Clq GN and SLE GN is the lack of endothelial tubuloreticular inclusions in Clq GN.The most interesting aspect of Clq GN is that although the glomerular changes resemble SLE GN by light microscopy and electron microscopy, these patients lack clinical or serological evidence for SLE. Specifically, serological tests for ANA, anti-DNA, and LE are all negative in Clq GN patients.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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