Abstract
This study examined the rates and persistence of clozapine-induced tachycardia and heart-rate differences in patients treated with β-blockers in the largest sample of patients with a psychotic disorder to date. An audit of medical files for 101 patients who attended a clozapine community clinic and analysis of monthly measurements of resting heart rates. 51% met the clinical criteria for tachycardia. Heart rates were stable over time. β-blockers were associated with small but significant reductions in heart rates. The cardiovascular risks of clozapine are often overlooked. β-blockers are useful in lowering heart rates but they may be insufficient to reduce cardiac risk.
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Schedule a callMore From: Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists
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