Abstract
Clozapine (1–10 mg/kg s.c.) produces a selective increase in dopamine release in rat prefrontal cortex which is, in large part (~50%), mediated via activation of 5-HT 1A receptors. Clozapine is a moderately potent, partial 5-HT 1A receptor agonist and activation of 5-HT 1A receptors may contribute to its efficacy against negative symptoms and reduced extrapyramidal side effect liability. Agonist affinity for 5-HT 1A receptors could thus be a desirable feature in the design of new antipsychotics.
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