Abstract
Clown therapy seems effective in reducing procedural pain in children, particularly for older age groups, but due to poor methodological quality and the high risk of bias of the studies included, the results obtained should be considered with caution. •Clown therapy is one of the most used techniques in the non-pharmacological management of acute pediatric pain. • Laughter physiologically stimulates the production of beta-endorphins, substances with an effect similar to opiates. •Clown therapy seems effective in reducing procedural pain and anxiety in children. •The intervention in school-age children or adolescents produces a statistically significant decrease in the symptom.
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