Abstract
A new method for the determination of the Cefixime drug in some Pharmaceuticals using ultra violet-visible (UV- Vis) and indirect Flame Atomic Absorption Spectrophotometry (FAAS) by Cloud point Extraction by using Triton X-114 as surfactant, the method based to form chelating complex CEF – Pd (II) at 456nm, variables parameters were studied such as the concentration of metal ion, effect of pH, Triton X-114 amount, equilibration temperature and incubation time. The best pH for the formation of chelating complex was (9). The best temperature on cloud-point extraction was 55 0C at 20 min. then complex extracted with ethanol. The mole-ratio method has been used to determine the structure of chelate CEF – Pd (II) and found to be 1:1 L:M (Ligand : Metal). Beer’s Law was obeyed in the range 2.5-30 and 2.5-32.5μg/mL for UVVis and FAAS respectively. Limit of Detection and Limit of Quantitation LOD and LOQ values for these methods were (0.456592, 0.33374) μg/mL (1.521976, 1.112471) μg/mL respectively.the method was validated and successfully applied to drug formulations like Cefix capsules marketed in Iraq. The results of analysis have been validated statistically and by recovery studies and were found satisfactory
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