Abstract
This paper proposes a cloud-based software architecture for fully automated point-of-care molecular diagnostic devices. The target system operates a cartridge consisting of an extraction body for DNA extraction and a PCR chip for amplification and fluorescence detection. To facilitate control and monitoring via the cloud, a socket server was employed for fundamental molecular diagnostic functions such as DNA extraction, amplification, and fluorescence detection. The user interface for experimental control and monitoring was constructed with the RESTful application programming interface, allowing access from the terminal device, edge, and cloud. Furthermore, it can also be accessed through any web-based user interface on smart computing devices such as smart phones or tablets. An emulator with the proposed software architecture was fabricated to validate successful operation.
Highlights
Infectious diseases are a major burden to global health and the economy, especially in developing countries [1,2,3,4,5]
ThreeMolecular types of Diagnostic web GUIsProcess were established to operate the emulator to demonstrate the validity of the proposed software architecture
This paper proposes a cloud-based software architecture for a fully automated POC
Summary
Infectious diseases are a major burden to global health and the economy, especially in developing countries [1,2,3,4,5]. Despite the significant efforts to enhance global health along with the advancement in health care technologies, reducing the number of deaths occurring annually in resource-limited settings remains a challenge [6]. Deploying point-of-care (POC) diagnostic equipment to developing countries can help overcome the economic burden that rises from scarce resources, which will enhance the medical care
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