Abstract
Outbreaks due to Clostridium difficile polymerase chain reaction (PCR) ribotype 027, toxinotype III, were detected in 7 hospitals in the Netherlands from April 2005 to February 2006. One hospital experienced at the same time a second outbreak due to a toxin A–negative C. difficile PCR ribotype 017 toxinotype VIII strain. The outbreaks are difficult to control.
Highlights
Outbreaks due to Clostridium difficile polymerase chain reaction (PCR) ribotype 027, toxinotype III, were detected in 7 hospitals in the Netherlands from April 2005 to February 2006
Measures taken by the hospital included isolating all patients with diarrhea until 2 tests were negative for C. difficile toxin, cohorting all C. difficile–infected patients on a separate ward, banning all fluoroquinolone use, and limiting use of cephalosporins and clindamycin
C. difficile PCR ribotype 027, toxinotype III, in English hospitals, this more virulent type was detected in the Netherlands [7,8]
Summary
Outbreaks due to Clostridium difficile polymerase chain reaction (PCR) ribotype 027, toxinotype III, were detected in 7 hospitals in the Netherlands from April 2005 to February 2006. The PCR ribotype 027, toxinotype III, strain is resistant to ciprofloxacin and the newer generation of fluoroquinolones, such as gatifloxacin, levofloxacin, and moxifloxacin [3]. The Outbreaks In July 2005, the medical microbiologic laboratory at the Leiden University Medical Center was requested to type C. difficile strains from an outbreak in a hospital (hospital l) in Harderwijk (Figure, Table).
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