Abstract

Clostridium difficile is a common cause of hospital-acquired diarrhea; in the past, outbreaks have been associated with use of antibiotics, particularly cephalosporins, clindamycin, or ampicillin-amoxicillin. After the incidence of nosocomial C. difficile disease at a large Pittsburgh hospital increased from 2.7 cases per 1000 discharges in 1999 to 6.8 cases …

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