Clostridium difficile-associated diarrhea after living donor liver transplantation

Abstract

To assess the incidence and analyze the risk factors for Clostridium difficile-associated diarrhea (CDAD) after living donor liver transplantation (LDLT) in adult. The microbiological data and medical records of 242 adult recipients that underwent LDLT at the Tokyo University Hospital were analyzed retrospectively. The independent risk factors for postoperative CDAD were identified. Postoperative CDAD occurred in 11 (5%) patients. Median onset of CDAD was postoperative d 19 (range, 5-54). In the multivariate analyses, male gender (odds ratio, 4.56) and serum creatinine (>or= 1.5 mg/dL, odds ratio, 16.0) independently predicted postoperative CDAD. CDAD should be considered in the differential diagnosis of patients with postoperative diarrhea after LDLT.