Closing the gap: from public concerns about health effects to science-based testing of chemicals

Abstract

Event Abstract Back to Event Closing the gap: from public concerns about health effects to science-based testing of chemicals Sergey Shaposhnikov1*, Gunnar Brunborg2 and Andrew Collins3 1 NorGenoTech, Norway 2 Norwegian Institute of Public Health, Department of Chemicals and Radiation, Norway 3 University of Oslo, Department of Nutrition, Norway The comet assay is a powerful technology for measuring DNA integrity in humans and other organisms at the level of individual cells. The assay is used for research and industrial testing but suffers from a lack of standardisation, which hinders its use on a larger scale, for example as a diagnostic tool in personalised medicine or as a standard industrial testing approach for assessing toxic effects of chemicals and drugs. A variety of comet assay equipment has been used by different research groups. Most is “homemade”, adapted from other related fields, or provided by commercial companies with no deep scientific understanding of the technology and comet community needs. Our goal is to close the gap between “in house” comet approaches used in a setting of a research lab and the release of modern comet equipment and services, which would combine attractive and functional design with high throughput sample analysis and a high degree of standardisation. European research labs, biomedical and chemical industries, as well as regulators will be among the customers. We have already made and put in use fully functional “in house” high throughput comet prototypes and have shown their scientific advantages over conventional comet technologies. The next step is to transform our homemade technology into a gold standard comet assay - a high throughput, integrated, user-friendly DNA damage testing facility. Acknowledgements The project is partly funded by French-Norwegian Foundation, Research Council of Norway Keywords: high throughput comet assay, Genotoxicity, DNA Damage, Drugs screening, biomedicine Conference: ICAW 2015 - 11th International Comet Assay Workshop, Antwerpen, Belgium, 1 Sep - 4 Sep, 2015. Presentation Type: Poster Discussion Topic: New applications and technical improvements Citation: Shaposhnikov S, Brunborg G and Collins A (2015). Closing the gap: from public concerns about health effects to science-based testing of chemicals. Front. Genet. Conference Abstract: ICAW 2015 - 11th International Comet Assay Workshop. doi: 10.3389/conf.fgene.2015.01.00063 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 May 2015; Published Online: 23 Jun 2015. * Correspondence: Dr. Sergey Shaposhnikov, NorGenoTech, Skreia, 2848, Norway, sas@norgenotech.no Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Sergey Shaposhnikov Gunnar Brunborg Andrew Collins Google Sergey Shaposhnikov Gunnar Brunborg Andrew Collins Google Scholar Sergey Shaposhnikov Gunnar Brunborg Andrew Collins PubMed Sergey Shaposhnikov Gunnar Brunborg Andrew Collins Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.