Abstract
In January, Neil Theise (New York University School of Medicine, NY, USA) and colleagues reported that normal, fully mature hepatocytes can derive from bone-marrow cells in the absence of severe acute liver injury 1 Theise N. et al. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology. 2000; 31: 235-240 Crossref PubMed Scopus (908) Google Scholar . ‘There is plenty of evidence for the existence of a facultative liver stem cell compartment in animals and humans but its anatomic location has proved difficult to locate. The suggestion that the liver stem cell may be a pluripotent bone-marrow cell has enormous implications,’ says Theise.
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