Abstract
Closed-loop intestinal obstruction, with and without hemorrhagic or ischemic strangulation, was studied in germ-free rats individually contaminated with one of three strains of Candida albicans. The principal findings were (a) C. albicans monocontamination of the unoperated germ-free rat was innocuous; (b) contamination of the segment, alone, was as lethal as contamination and strangulation; (c) monocontamination of the closed segments, with and without strangulation, with either strain NIH 792 or ATCC 10261 killed over 30% of the animals although ATCC 10259 had no obvious effect; and (d) ATCC 10261 was associated with late postoperative intestinal bleeding and death. Ancillary findings in a group of C. albicans monocontaminated, but unoperated, germ-free rats were (a) there were rather uniform concentrations of viable C. albicans throughout the gastrointestinal tract; and (b) the serum proteins of these animals showed increased levels of total protein, alpha-2, and beta, but not gamma globulins, in comparison to germ-free rats.
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