Closed drainage under negative pressure combined with flap transplantation for large area skin defects in limbs

Abstract

Objective To evaluate the value of closed drainage under negative pressure combined with flap transplantation for large area skin defects in limbs. Methods 80 patients with large area skin defects in limbs treated at our hospital from June, 2013 to December, 2016 were randomly divided into a control group and an observation group, 40 for each group. The control group were treated with routine debridement and the observation group closed drainage under negative pressure and Ⅰ stage flap transplantation. All the patients were followed up for 3 months. The dressing, wound recovery, and wound healing before and 2 weeks after intervention were calculated. Results The dressing times was (3.8 ± 0.6)in the observation group and (7.3 ± 1.2) in the control group (t=16.499, P<0.05). The wound recovery rate was (47.4 ± 2.9)% in the observation group and (16.4 ± 1.2) in the control group (t=62.470, P<0.05). The wound healing time was (25.3 ± 1.8) d, in the observation group and (33.2 ± 2.7) d in the control group (t=15.397, P<0.05). The levels of TNF-α, IL-1, and hs-CRP were (12.1 ± 0.2) ng / mL, (0.61 ± 0.1) μg / mL, and (10.5 ± 1.0) mg / L in the observation group and were (18.3 ± 0.5) ng/ml, (0.93 ± 0.2) μg / ml, and (31.1 ± 2.0) mg/L in the control group (t=72.815, 9.051, 58.266, all P<0.05). Conclusion Negative pressure drainage can improve the inflammation and reduce dressing times and shorten the wound healing time. Key words: Closed drainage under negative pressure; Flap transplantation; Limbs; Large area skin defect